EFFECTS OF THE ROOT BARK EXTRACT OF Monotheca buxifolia (FALC.) A. DC ON ANTIOXIDANT POTENTIAL AND SERAL PROPERTIES OF RABBIT (Oryctolagus cuniculus)
AbstractThis activity was aimed to examine the phytomedicinal effects of the crude extract of the bark of the root of Monotheca buxifolia (Falc.) A. DC on the serum biochemistry and antioxidant potential of the in-vitro lipids present in various tissues of the rabbits and the overall correlation of the extract and serum lipids. The extract was administered orally to the rabbits in different doses (0, 25, 75 and 150 mg) in triplicate daily for 10, 20 and 30 days respectively. The data showed that the weights of rabbits and their different organs were reduced. Serum cholesterol level of the experimental animal decreased, while no variation in the serum glucose was observed. The histopathology results showed that the central vein had normal endothelial lining with no evidence of pericentral fibrosis. The hepatic cords in almost all cases were well formed. The portal tracts showed branches of hepatic artery, portal veins and cholengioles with normal morphology. A significant (P < 0.05) reduction was observed in the RSA values of the brain, liver and muscles of the subject animals. Increasing the dose reduced the RSA values in all the tissues. It was concluded that this plant has the potency for decreasing weight of the whole body and also decrease the cholesterol level without significantly affecting other parameters. Hence, there are implications for further detailed studies on this plant.